南方女性复发性流产环境因素分析

Study on the risk factors for unexplained recurrent spontaneous abortion in southern Chinese women

目的:探讨南方女性不明原因复发性流产(undentifiedrecurrentspontaneousabortion,URSA)流行病学因素。方法:对326例URSA及400例正常对照育龄妇女进行健康问卷调查,用Logistic回归模型,纳入体重指数(BMI)、自然流产家族史、吸烟史、被动吸烟史、饮酒史、饮咖啡史,找出有独立意义的环境危险因素,并对自然流产次数3次及≥4次者进行分层分析。结果:吸烟史、饮酒史和饮咖啡史不是URSA的危险因素,短时间被动吸烟(<1h/天)及长时间被动吸烟(≥1h/天)是URSA的危险因素,OR及95%CI分别是2.30,1.50～3.52及4.76,3.24～6.99。家族史及BMI≥24.0kg/m2是URSA危险因素,OR及95%CI分别是2.12,1.28～3.49及1.55,1.12～2.14。结论:被动吸烟史、BMI≥24.0kg/m2、自然流产家族史是中国南方女性URSA独立危险因素。

Objective：To investigate epidemiologic factors for unexplained recurrent spontaneous abortion （RSA） in southern Chinese women.Methods：The association between BMI,family abortion history,smoking,environmental tobacco smoking （ETS;passive smoking）,alcohol consumption,coffee intake,and URSA were analyzed with a logistic regression model involving 326 patients with unexplained recurrent spontaneous abortion and 400 control cases.The independent environmental risk factors were identified,and the patients with spontaneous abortions 3 times and ≥ 4 times were stratified analyzed.Results：There was no positive association between smoking,alcohol consumption,coffee intake,and URSA.Short ETS （ 1 hour/day） was associated with an increased risk of RSA （adjusted OR,2.30;95% CI=1.50-3.52） and long ETS （≥1 hour/day） had an increased risk （adjusted OR,4.75;95% CI=3.23-6.99）.The increased risk of URSA was significant in those with a positive family history （adjusted OR,2.12;95% CI=1.28-3.49） and those with a BMI ≥24.0 kg/m2 （adjusted OR,1.55;95% CI=1.12,2.14）.Conclusion：ETS,increased BMI （≥24.0 kg/m2）,and family abortion history are independent risk factors for URSA in southern Chinese women.