不同孕周妊娠妇女血清总胆汁酸检测结果分析

Results analysis of detecting serum total bile acid in pregnant women with different gestational age

目的了解正常不同孕周孕妇血清总胆汁酸的含量,以及在妊娠过程中总胆汁酸的变化特征及临床意义。方法采用BeckmanCX4全自动生化仪检测580例正常孕妇,400例非妊娠健康妇女血清总胆汁酸(TBA)。结果正常妊娠过程血清TBA有升高趋势,TBA浓度在中孕时开始明显升高。早孕、中孕和晚孕组的孕妇血清中TBA水平分别较非妊娠组升高14.4%、49.7%和65%,而且晚孕组比中孕组的孕妇血清中TBA水平也有明显升高。结论妊娠过程TBA水平持续升高,且明显高于同孕龄正常孕妇,应定期作TBA检测和动态观察,有利于妊娠肝内胆汁淤积症(ICP)及早预防和诊治。

Objective To understand the serum content of total bile acid in the normal pregnant women with different gestational age and its change characteristics and clinical significance during pregnancy.Methods Backman CX4 automatic biochemical analyzer WAS USED TO detect serum total bile acid （TBA） in 580 cases of normal pregnant women,400 cases of non-pregnant healthy women.Results The serum TBA in the course of normal pregnancy tended to increase.The TBA concentration increased significantly in middle pregnancy.In the early,middle and late pregnancy groups of pregnant women,the serum TBA levels were higher than that in non-pregnant group by 14.4%,49.7% and 65%,and the TBA level in late pregnancy group was obviously higher than that in middle pregnancy group.Conclusion TBA level continues to rise during pregnancy,which is significantly higher than that in normal pregnant women with same gestational age.Should regularly detect and dynamically observe TBA,which is conducive to early prevention and treatment of intrahepatic cholestasis of pregnancy （ICP）.