hs-CRP和WBC联合检测在儿童呼吸道感染中的应用

Appliccation of Hs-CRP and WBC combined detection in children with respiratory tract infections

目的探讨联合全血超敏C-反应蛋白(hs-CRP)和白细胞(WBC)计数在儿童呼吸道感染中的应用价值。方法选取铜陵市人民医院急性上呼吸道感染的患儿350例,其中新生儿50例,婴儿100例以及儿童200例,对照组30例在校小学生,分别检测外周血hs-CRP和血常规,另从婴儿组和儿童组分别选取细菌感染、支原体感染和病毒感染各40例,与对照组比较。结果新生儿组hs-CRP的升高率为38%,WBC的升高率只有1%;婴儿组hs-CRP的升高率44%,WBC的升高率为13%;儿童组的hs-CRP升高率为61%,WBC的升高率为41%。另病毒感染的hs-CRP、WBC与对照组比较,差异有统计学意义(P>0.05);细菌组和支原体组与对照组比较差异有统计学意义(P<0.01),且细菌组高于支原体组,差异有统计学意义(P<0.01)。结论联合检测hs-CRP和WBC对儿童上呼吸道感染的鉴别具有重要价值。

Objective To explore the application value of joint detection of whole-blood high-sensitivity C-reactive protein （hs-CRP） and white blood cell count （WBC） in children with acute respiratory infections.Methods To select 350 cases of acute upper respiratory tract infection in our hospital,including 50 neonats,100 infants as well as 200 children,30 pupils as the control group. hs-CRP in peripheral blood was detected and the routine blood test was performed. 40 cases in each of bacterial,mycoplasma and viral infections were selected from the infantile and children groups and copmared with the control group.Results In neonatal group,the hs-CRP positive rate was 38%,WBC positive rate was only 1%; in infantile group,the hs-CRP positive rate was 44%,the WBC positive rate was 13%; in children group,the hs-CRP was 61%,the WBC positive rate was 41%. In viral infection,hs-CRP and WBC had statistical difference compared with the control group,（P0.05）; mycoplasma and bacterial groups had statistical difference compared with the control group （P0.01）,and the bacterial group was higher than mycoplasma group with the statistical difference （P0.01）.Conclusion Combined detection of hs-CRP and WBC has great value in differentiating upper respiratory tract infections in children.