32例低增生性骨髓增生异常综合征的实验室诊断并文献复习

Laboratory diagnosis of hypoplastic myelodysplastic syndrome in 32 cases and literature review

目的探讨低增生骨髓异常增生综合征(Hypo-MDS)的临床特点及Hypo-MDS与慢性再生障碍性贫血(CAA)的鉴别要点。方法对32例Hypo-MDS患者初发病时的血象、骨髓象、骨髓病理及细胞遗传学方面进行分析总结。结果 Hypo-MDS是MDS病程中的一个阶段,特征为骨髓病态造血和低细胞容积;Hypo-MDS的诊断,需综合细胞形态学、骨髓病理学及细胞遗传学,但骨髓病理切片比骨髓涂片更有价值。结论 Hypo-MDS与CAA的临床表现、血象及骨髓涂片有相似点,骨髓病理切片、细胞遗传学检查有差异。

Objective To explore the clinical characteristics of hypoplastic myelodysplastic syndrome （Hypo-MDS） and its differential diagnosis with the chronic aplastic anemia（CAA）.Methods 32 patients with Hypo-MDS were carried out the analysis from multiple angles,such as clinical course,blood routine examination,bone marrow cytology,bone marrow biopsy,cytogenetics.Results Hypo-MDS is a stage in the course of MDS.The meta analysis showed that the morphocytology,pathology of bone marrow and cytogenetics were needed for the diagnosis of Hypo-MDS.The similarities were found between Hypo-MDS and CAA in clinical features,hemogram and bone marrow slides.Conclusion In contrast ,there were differences in pathological section and cytogenetics.