摘要
目的:研究盐酸阿扎司琼氯化钠注射液中盐酸阿扎司琼的定量分析方法。方法:采用高效液相色谱法.色谱柱:Shim-PackCLC-ODSC_(18)(250mm×4.5mm,5μm)分析柱;流动相:磷酸二氢钾-乙腈(95:5V/V),流速:0.5mol·ml^(-1);测定波长216nm;柱温40℃。结果:盐酸阿扎司琼在2.5～15μg·ml (r=0.9997,n=6)呈现良好的线性关系,平均回收率为99.23%,RSD为0.73%。结论:本方法操作简便、精密度好,适用于盐酸阿扎司琼氯化钠注射液的质量控制。
OBJECTIVE：To establish the HPLC method for the determination of Azasetron Hydrochloride and Sodium Chloride Injection.METHODS： HPLC was performed on Shim-pack CLC-ODS （250mm×4.5mm,5μm） with potassium dihydrogen phosphate - acetonitrile （95：5） as mobile phase, detecting wavelength was 216nm.RESULTS：The calibration curve is linear in the concentration range of 2.5-15μg-ml^-1（r=0.9997, n=6）. CONCLUSION：This method is simple, accurate, repeatable and effective for quality control of Azasetron Hydrochloride and Sodium Chloride Injection .
出处
《内蒙古中医药》
2010年第17期125-125,127,共2页
Inner Mongolia Journal of Traditional Chinese Medicine
