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高效液相色谱法测定肾康宁胶囊中丹参素的含量 被引量:8

Determination of Salvianic Acid A in Shenkangning Capsule by HPLC
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摘要 目的应用高效液相色谱法测定肾康宁胶囊中丹参素的含量。方法采用Shim-pack-C18柱(5μm,150mm×4.6mm),以[甲醇-乙腈(1:1)]-2%醋酸水溶液(4:96)为流动相,流速为0.8mL/min,检测波长为283nm。结果丹参素线性范围为0.2167~1.0836μg,r=0.9998。丹参素的回收率为98.21%,RSD=0.78%。结论该方法用于测定肾康宁胶囊中丹参素的含量,具有简便、准确、灵敏的特点,可作为该制剂质量控制的方法。 Objective To determine the content of Salvianic acid A in Shenkangning Capsule by high performance liquid chromatography. Methods The determination was carried out on Shim-pack-C18 column (5μm, 150 mm×4.6mm), eluted with the mobile phase of methanol-acetonitrile (1 : 1) containing 2% acetic acid (4 : 96). The flow rate was 0.8 mL/min and the detection wavelength was 283 nm. Results A good linear relationship between the peak area and injection amounts for Salvianic acid A was found within 0.216 7~1.083 6μg, with a correlation coefficient of 0.999 8. The average recovery of Salvianic acid A was 98.21%, RSD was 0.78%. Conclusion The method is simple, accurate, sensitive and can be applied to the quality control of the preparation.
出处 《中国中医药信息杂志》 CAS CSCD 2010年第10期49-50,共2页 Chinese Journal of Information on Traditional Chinese Medicine
关键词 高效液相色谱法 丹参素 肾康宁胶囊 含量测定 HPLC Salvianic acid A Shenkangning Capsule content determination
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