细胞角质蛋白对诊断子宫内膜癌淋巴微转移的研究

Study on cytokeratin in the diagnosis of endometrial cancer with lymph node micrometastases

目的:探讨细胞角质蛋白(CK)对诊断子宫内膜癌淋巴微转移的意义及影响其检出率的因素。方法:对2005年1月～2009年6月在吉林省肿瘤医院妇瘤科及吉林大学第二医院进行手术治疗且经一般病理诊断40例子宫内膜癌患者无转移的淋巴结240枚(实验组1)和80例子宫内膜癌患者有转移的淋巴结440枚(实验组2)临床资料进行回顾性分析。结果:病理诊断阳性的淋巴结CK检测全部阳性,病理诊断阴性的淋巴结CK检测并非全部阴性,阳性率提高了19.2%(46/240),经单因素分析肿瘤组织分化程度、浸润深度、病理类型及手术分期均影响其检查的因素(P<0.05)。结论:CK能够提高淋巴结阳性的检出率,从而正确行子宫内膜癌手术-病理分级,指导子宫内膜癌的术后辅助治疗,提高预后。

Objective：To evaluate cytokeratin （CK） in the diagnosis of endometrial cancer, the significance of lymph node micrometastases and the factors affecting the detection rate.Methods：40 cases of endometrial cancer patients without metastasis in the lymph nodes 240 （experimental group 1） and 80 cases of endometrial cancer patients with metastatic lymph nodes 440 （experimental group 2） were selected from January 2005 to June 2009, in Jilin Province tumors Hospital and Jilin University Second Hospital to retrospectively analyze the clinical data of surgical treatment and ordinary pathological diagnosis.Results：The pathological diagnosis of positive lymph nodes, CK test all the positive, negative lymph node pathology, CK testing was not all negative, the positive rate of 19.1% （46/357）.. After univariate analysis： tumor differentiation, depth of invasion, pathological type, and surgical staging were the inflential factors （P〈0.05）.Conclusion：CK can improve the detection rate of lymph node-positive, thus the correct line of endometrial cancer surgery-pathological grade, guidance endometrial cancer adjuvant therapy could improve prognosis.