西宁地区糖尿病合并胆结石患者胰岛素、血糖、血脂水平分析

ANALYSIS OF CLINICAL FEATURES AND LEVELS OF INSULIN,BLOOD SUGAR AND LIPID IN DIABETIC PATIENTS WITH GALLSTONE AT XINING

目的探讨西宁地区糖尿病合并胆结石者的临床特点及其胰岛素、血糖、血脂水平与胆结石的关系。方法收集180例2型糖尿病患者,其中胆结石者82例。对合并胆结石者性别、年龄、体重指数、血糖、血胰岛素及脂代谢异常等相关因素进行分析,并与98例无胆结石者进行对比。结果糖尿病合并胆结石女性患病率高于男性(P<0.01),胆结石患病率随年龄的增长而增高;与无胆石症组相比,合并胆结石组空腹血糖、糖化血红蛋白、血清胰岛素和C肽水平显著增高(P<0.01);无胆结石组仅甘油三脂及胆固醇较对照组升高(P<0.05),与无胆石症组相比,胆石症组胆固醇、低密度脂蛋白、载脂蛋白B水平显著增高,而高密度脂蛋白、载脂蛋白A则明显降低(P<0.01)。结论脂代谢紊乱、高血糖、高胰岛素血症、肥胖可能是西宁地区糖尿病合并胆结石的危险因素。

Objective To analyze the clinical features of cholelithiasis in patients with diabetes at Xining,and analyze the relationship of gallstone to insulin,blood sugar and lipid level in those patients.Methods 180 patients with diabetes were enrolled and divided into two groups according to the result of B-ultrasonic examination： 82 cases with cholelithiasis and 98 cases without cholelithiasis.Relative factors including sex,age,body mass index（BMI）,levels of insulin,blood sugar and lipid were compared between the two groups.Results The female had higher prevalence of cholelithiasis complication than male in diabetes patients（P0.01）.Cholelithiasis prevalence increased with age.Patients with cholelithiasis had higher levels of fasting plasma glucose,HbA1c,insulin,C-peptide,total cholesterol（TC）,triglycerides（TG）,low density lipoprotein-cholesterol（LDL） and apolipoprotein-B（APO-B） than patients without cholelithiasis（p0.01）,while the levels of high density lipoprotein（HDL） and apolipoprotein-A（APO-A） were lower（P0.05）.Conclusion Dislipidemias,high blood sugar,hyperinsulinemia,obesity may be the risk factors for the development of cholelithiasis in patients with diabetes in Xining.