甲酸钠对辐射损伤的抑制作用

Radioprotective effect of sodium formate

目的：研究甲酸钠对辐射损伤的抑制作用。方法：采用溶血试验，受照小鼠肝、肾组织谷胱甘肽测定，受照质粒 Ｐ Ｕ Ｃ１９ Ｄ Ｎ Ａ 链断裂测定作为检测指标。结果：甲酸钠能明显抑制紫外线致红细胞溶血作用（ Ｐ＜ ００１） ；明显提高经６０ Ｃｏ γ射线照射的小鼠肝、肾组织谷胱甘肽水平（ Ｐ＜ ００５ 或 Ｐ＜ ００１） ；明显抑制经６０ Ｃｏ γ射线照射的质粒 Ｐ Ｕ Ｃ１９ 超螺旋构象百分率的下降（ Ｐ＜ ００５ 和 Ｐ＜００１） 。结论：甲酸钠能清除辐射引起的自由基损伤，具有防辐射作用。

Aim: To assess the radioprotective effect of Sodium Formate (SF). Methods: used hemolysis, GSH level of mice tissue homogenate and the change of conformation of plasmid PUC 19 as indexes. Results:SF reduced significantly hemolysis degree of erythrocyte suspensions irradiated by UV ( P <0 01). SF improved GSH levels of mice liver and kidney homogenates when mice were exposed to 6 Gy of 60 Coγ-rays ( P <0 05 or P <0 01). SF raised the percentage of supercoil conformation of PUC 19 irradiated by 100 Gy of 60 Co γ-rays compare with control group ( P <0 05 or P <0 01). Conclusion: SF scavenged free radical damage caused by UV of γ-irradiation, it has radioprotective effect.