飞龙掌血水提取物对大鼠实验性心肌梗死的保护作用

Protective effects of aqueous extract of Toddalia Asiatica on experimental myocardial infarction in rats

目的：观察飞龙掌血（ Ｔｏｄｄａｌｉａ ａｓｉａｔｉｃａ ｌａｍ） 水提物（ 飞龙一号， Ｆ０１） 对冠脉动脉阻塞性心肌缺血性损伤的保护作用。方法：结扎冠脉动脉前降支制备 Ｓ Ｄ 大鼠心肌缺血模型，观察药物对动物心电图 Ｔ 波、 Ｓ Ｔ 段、病理性 Ｑ 波等变化和心肌梗死范围的影响。结果： Ｆ０１（１７５ 、３００ ｍｇ·ｋｇ１） 能明显缓解 Ｔ 波、 Ｓ Ｔ 段、病理性 Ｑ 波的心电图改变，并使心肌梗死范围缩小，其效应与剂量相关，并与维拉帕米相似。结论： Ｆ０１ 对结扎冠脉前降支所致心肌梗死有显著保护作用，该作用可能与抑制 Ｃａ２ ＋

Aim:To observe the protective effects of Toddalia asiatica aqueous extract (Fei Long No 1, F01) on acute ischemic myocardium caused by coronary artery occlusion. Methods: The experimantal myocardial infarction was induced by ligating the left anterior descending coronary artery of rats. The changes of T wave amplitude and ST segment elevation in the rat ECG were determined. The occurrence of pathological Q wave (NQ) was counted. The myocardial infarction size (MIS) was determined by nitro-blue tetrazolium stain. t-test and Fisher' exact test were used for the statistical analysis. Results: The changes of T wave amplitude and ST segment elevation were attenuated by F01 (175～300 mg·kg 1 ) significantly, and ∑ST, NST, NQ and MIS were reduced markedly. These effects were correlated with the dosed and similar to that of verapamil. Conclusions: F01 possessed protective effects on the ischemic myocardium caused by coronary artery occlusion. These effects probable result from its vasodilative effects through inhibiting Ca 2+ movement.