恶性血液病患者血液粘滞度测定及临床意义

Blood viscosity of malignant hematonosis patient and its clinical significance

目的：探讨４ 种恶性血液病患者血液粘滞度变化规律和在临床上的意义。方法：通过血液流变学测试仪测定４４ 例恶性血液病患者及４０ 例正常人血液粘滞度指标，并进行多因素相关性分析。结果：急性白血病（ Ａ Ｌ） 患者全血粘度（ηｂ） 降低，血浆粘度（ηｐ） 正常；慢性粒细胞白血病（ Ｃ Ｍ Ｌ） 与非霍杰金氏淋巴瘤（ Ｎ Ｈ Ｌ） 患者ηｂ 升高，ηｐ 正常；多发性骨髓瘤（ Ｍ Ｍ） 患者ηｂ 、ηｐ 升高。结论：４ 种恶性血液病患者存在不同特征的血液粘滞度异常，分析其改变有助于对病情判断和指导治疗。

Aim: To elucidate various rules of blood viscosity of 4 kinds of malignant hematonosis patients. Methods: Blood viscosoty of 44 malignant hematonosis patient and that of 40 normal controls, were analyzed by multifactor interrelation analysis. Results: Blood viscosity (ηb) of acute leukemia (AL) patients decreased and plasma viscosity (ηP) remained normal; ηb of chronic granulocytic leukemia (CML) and non Hodgkin lymphoma (NHL) increased with normal ηP. For multiple myeloma (MM) patient, both of ηb and ηP increased. Conclusion: There are different characters of abnomal blood viscosity in 4 kinds of malignant hemetonosis patients. To analyse hemorheolgy index is helpful to the determination of their condition and direction of treatments.