鸡屎藤中环烯醚萜化合物的制备与鉴定

Preparation and identification of iridoid compounds in Paederia scandense

目的:本文对鸡屎藤95%乙醇提取物进行了化学成分研究.方法:采用D101-大孔树脂对环烯醚萜化合物进行富集,并对30%乙醇-水洗脱部分进行分离纯化,反复进行硅胶,ODS,Sephadex LH-20柱层析,通过理化常数和波谱分析进行化合物的结构鉴定.结果:分离到5个环烯醚萜化合物,鉴定为Saprosmoside E(1),鸡屎藤苷(paederoside,2),鸡屎藤酸(paederosidic acid,3),鸡屎藤酸甲酯(paederosidic acid methyl ester,4)以及去乙酰车叶草苷酸甲酯(deacetyl asperulosidic acid methyl ester,5).结论:其中去乙酰车叶草苷酸甲酯为首次从该植物中分离得到.

Objective：To study iridoids in 95% ethanol extract from stems of Paederia scandense.Method：Iridoids are enriched by D101-macroporous resin.The constituents of the moiety of 30% aqueous EtOH are isolated and purified by silica gel,ODS and sephadex LH-20 column choromatography.The structures of the isolated iridoids are elucidated by physical-chemical properties and spectral analysis.Result：Five iridoids are obtained and identified as Saprosmoside E（1）,paederoside（2）,paederosidic acid（3）,paederosidic acid methyl ester（4）,deacetyl asperulosidic acid methyl ester（5）.Conclusion：Compound 5 is isolated from this plant for the first time.