血清肝纤标志物的临床应用价值探讨

The Clinical Practical Value of the Serum Indexes of Liver Fibrosis in Patients with Chronic Liver Disease

目的:探讨血清透明质酸(HA)、层黏蛋白(LN)、Ⅲ型前胶原(PCⅢ)及Ⅳ型胶原(CⅣ)对慢性肝病患者肝纤维化的诊断价值。方法:采用放射免疫分析法检测232例肝病患者的HA、LN、PCⅢ、CⅣ值,并与正常对照组相比较。结果:各型肝病患者血清中HA、LN、PCⅢ、CⅣ水平随着病情发展而升高。与正常对照组相比较,HA、LN各组均明显升高;PCⅢ、CⅣ在慢性肝炎轻度组无显著变化,而在重度肝炎中升高最为显著。结论:联合检测肝纤标志物对于动态观察慢性肝病的进展和预后有较高的临床应用价值。

Objective：To detect the diagnosis value of the serum HA、LN、PCⅢ and CⅣ for liver fibrosis in patients with chronic hepatitis.Methods：The serum levels of HA、LN、PCⅢ and CⅣ were detected by radioimmunoassay（RIA） from 232 hepatitis patients,and compared with the normal group.Results：It was found that the serum level of the HA、LN、PCⅢ and CⅣ were increased with the progression of the disease in patients with various types of liver disease,the level of HA and LN in each experimental group were significantly higher,compared with the normal group.PCⅢ and CⅣ were no significant change in mild chronic hepatitis,but they were increased significantly in severe hepatitis.Conclusion：To use united-detection of hepatic-fibrosis markers for the dynamic observation of the progress and prognosis of chronic liver disease have a high clinical value.