凝血酶调节蛋白临床研究进展

The Progress of Thrombomodulin Clinical Research

凝血酶调节蛋白(Thrombomodulin,TM)是血管内皮细胞膜上的一种糖蛋白,可与凝血酶相结合,最终作用于蛋白C,在机体抗凝机制中发挥重要的作用.凝血酶调节蛋白及其衍生物血浆凝血酶调节蛋白(Plasma Thrombomodulin,PTM)或称可溶性凝血酶调节蛋白(Soluble Thrombomodulin,sTM)与一些临床疾病,例如恶性肿瘤、糖尿病、冠心病、急性白血病、多发性骨髓瘤等有一定的相关性,文章就它们之间关系的临床应用研究做一综述.

Thrombomodulin （ TM）, a cell surface glycoprotein of endothelial cells, whose ultimate effect is to activate protein C when bound with thrombin, plays an important role in the regulation of blood coagulation of the body. Thrombomodulin and its derivatives, plasma thrombomodulin （PTM）, sometimes called soluble thrombomodulin （ sTM）, are correlative with many clinical diseases, such as cancer, diabetes, crown heart disease, acute leukemia, multiple myeloma, etc. This paper endeavors to make a review of the related clinical application studies.