麻疹疑似病例141例血清中IgM抗体检测结果及病例分析

IgM Test Results and Analysis of 141 Suspected Measles Cases

目的探讨检测麻疹IgM抗体对分析麻疹流行病学特征的意义。方法对江苏省如东县2006—2009年141例麻疹疑似病例采集血清标本,应用酶联免疫吸附试验(ELISA)捕获法检测麻疹IgM抗体,对检测结果应用χ2检验进行统计学处理。结果 141例麻疹疑似病例血清标本,麻疹IgM抗体阳性109例,阳性率77.30%。11～20岁年龄组阳性率最高,达90.32%;31～40岁组次之,为84.78%。在病例的职业构成中农民占45.68%。在病例的免疫史分布中,无免疫史、免疫史不详者合计达69.14%。结论该县麻疹发病有向大年龄组发展的趋势,农民为重要的发病人群。加强麻疹疫苗接种管理尤其是农村的管理、针对成人的后续强化免疫和应急接种对控制疫情的传播具有重要意义。

[ Objective] To discuss the significance of measles IgM in analysis of epidemiological characteristics of measles. [ Methods] The serum samples Of 141 suspected measles cases in Rudong County of Jiangsu Province during 2006 -2009 were detected for measles IgM by ELISA. The results were analyzed statistically byx^2 test. [ Results] Of 141 serum samples, 109 were measles IgM positive, the positive rate was 77.30%. 11 -20 years age group had the highest positive rate of 90.32%, followed by 30 -40 years age group（84.78% ）. Regarding the occupation structure of the measles cases, the positive rate of farmers reached 45.68%. Patients without immunization history or with unclear immunization history occupied 69.14%. [ Conclusion] The measles epidemic has the tendency of spreading more easy in old age groups in this county, the peasants are the group with high-risk of measles. Strengthe- ning the management of measles vaccination, especially the management in rural area, follow-up supplementary immunization of adults and emergency vaccination, plays an important role in control the spread of measles.