依那普利辅助治疗慢性肺心病患者对血浆内皮素-1水平的影响

Effect on plasma ET-1 level in enalapril's accessory treatment for chronic cor pulmonale

目的探讨依那普利对慢性肺心病的治疗机制。方法对１９例慢性肺心病患者采用依那普利加常规治疗，疗程１０ｄ，观察治疗前后血浆内皮素－１（ＥＴ１）水平的变化，并与常规治疗组的１８例慢性肺心病患者血浆ＥＴ１水平变化进行比较。结果治疗后两组慢性肺心病患者血浆ＥＴ１水平较治疗前均明显下降（Ｐ＜０．０１），并以依那普利加常规治疗组血浆ＥＴ１水平下降幅度大和常规治疗组比较有统计学意义（Ｐ＜０．０５）。结论依那普利有明显降低慢性肺心病血浆ＥＴ１的作用。

Objective To explore the enalapril's therapeutic mechanism for chronic cor pulmonale.Methods 37 patients with chronic cor pulmonale were divided into two groups,i.e. enalapril +routine treatment group (19 cases )and routine treatment group (18 cases).Plasma endothelin(ET-1)level of all cases were determined and compared prior to and after 10- days treatment. Results Plasma ET-1 levels in both groups decreased evidently ( P <0.01) after 10-days treatment,and the decreasing trends were of statistic difference in two groups ( P <0.05),the first group was more fast than the second group.Conclusions Enalapril has a great effect on reducing plasma ET-1 level of chronic cor pulmonale patients.