慢性肾衰竭患者甲状旁腺激素变化与心脑血管事件的关系

Relationship between parathyroid hormone changes in patients with chronic renal failure and cerebrovascular events

目的研究慢性肾衰竭（CRF）患者血清甲状旁腺激素（iPTH）水平、钙磷代谢紊乱状况与心脑血管事件的关系。方法对87例CRF患者的临床及实验室资料作回顾性研究，未发生心脑血管事件病例为A组（66例），发生心脑血管事件病例为B组（21例），分析两组iPTH水平、血钙、血磷、钙磷乘积与心脑血管事件的关系。结果慢性肾衰竭患者血iPTH水平减低、血清C反应蛋白升高与心脑血管事件有关，血钙、血磷、钙磷乘积与心脑血管事件无关。透析组患者比非透析组患者发生心脑血管事件显著的增多。结论慢性肾衰竭透析患者血iPTH水平、CHP水平、透析治疗均可导致心脑血管事件的发生。

Objective To investigate the relationship of iPTH levels, calcium and phosphorus metabolism with cardiovascular event status in the chronic renal failure （CRF） patients. Methods This article retrospectivly studied the clinical and laboratory data of 87 CRF patients. 66 patients of A group didnt occur cardiovascular events, and 21 cases of B group occurred cardiovascular and cerebrovascular events. This article analyzed iPTH levels, serum calcium, phosphorus, calcium and phosphorus product and the relationship between cardiovascular and cerebrovascular events between the two groups. Results Decreased iPTH,increased serum C reactive protein and increased lipoprotein（a） had relationship with cardiovascular and cerebrovascular events in patients with chronic renal failure, but calcium, phosphorus, calcium and phosphorus product has nothing to do with the cardiovascular and cerebrovascular events. Cardiovascular and cerebrovascular events increased significantly in dialysis patients than in non - dialysis patients. Conclusion Chronic renal failure patients on dialysis levels of serum iPTH,CRP level, LP（a） level and dialysis could lead to cardiovascular and cerebrovascular events.