硝普钠、多巴胺及多巴酚丁胺联合治疗顽固性心力衰竭30例分析

Nitoprusside,dopamine and dobutamine for treatment of refractory heart failure

目的观察硝普钠、多巴胺以及多巴酚丁胺治疗顽固性心力衰竭的临床疗效。方法将60例顽固性心力衰竭患者随机分成对照组和治疗组，对照组30例常规给予吸氧、休息、限盐、抗感染，强心、利尿及扩血管；治疗组30例在对照组治疗基础上给予硝普钠、多巴胺以及多巴酚丁胺微量泵静脉注入，两组疗程均为7d，观察两组临床症状、体征、心脏彩超等变化。结果治疗组总有效率86．67％，对照组总有效率66．67％，总有效率两组对比差异有统计学意义（P〈0．05）。治疗后治疗组左室射血分数（LVEF）较对照组明显改善，差异有统计学意义（P〈0．05）。结论硝普钠、多巴胺以及多巴酚丁胺治疗顽固性心力衰竭是安全有效的方法。

Objective To observe the clinical effect of nitroprusside, dopamine and dobutamine for treatment of refractory heart failure. Methods 60 patients with refractory heart failure were randomly divided into control group and treatment group. Clinical symptoms, signs, echocardiography and other changes were observed. Results The total effective rate was 86.67% ,control group was 66.67% ,the total effective between the two groups was statistically significant（P 〈 0. 05 ）. After treatment, left ventricular ejection fraction （LVEF） improved significandy compared with the control group, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion The Sodium nitroprusside, dopamine and dobutamine for treatment of refractory heart failure was safe and effective method.