拉米夫定联合干扰素治疗慢性乙型肝炎疗效分析

The curative effects of Lamivudine oecombined with IFN in treatment of chronic hepatitis B

目的观察干扰素α-1b（IFNα-1b）联合拉米夫定治疗慢性乙型肝炎的效果。方法120例慢性乙型肝炎患者随机分为三组，各40例。干扰素组（A组）300万IU的IFNα-1b注射3次／周，共26周；拉米夫定组（B组）100mg口服，1次／d共52周；联合治疗组（C组）分阶段联合应用干扰素α-1b和拉米夫定治疗，疗程52周。治疗结束后，检测乙肝的血清学指标，评价治疗效果。结果治疗后三组的谷丙转氨酶（ALT）和谷草转氨酶（AST）均下降（P〈0．01），C组显著低于A组和B组。C组的有效率高于其他两组。结论干扰素α-1b联合拉米夫定治疗慢性乙型肝炎效果优于单独用药。

Objective To explore the curative effects of Lamivudine combined with IFNα-1 b in treatment of chronic hepatitis B. Methods 120 patients with chronic hepatitis B were divided into 3 groups. Patients in group A were treated with IFNα-2b 3 times a week for 26 weeks. Patients in group B were treated with Lamivudine one time a day for 52 weeks. Patients in group C were treated with IFNα-1b and Lamivudine symphysially. The serum indexes were observed and the clinical effects were evaluated. Results The ALT and AST levels in 3 groups were all decreased significantly（ P 〈 0. 01 ） after treatment. However, the ALT and AST in group C was lower than that of the other 2 groups（ P 〈 0. 05 ）. Also there was a statistical difference（ P 〈 0. 05 ） between the effective rate of the group C and that of other 2 groups. Conclusion Treating chronic hepatitis B with Lamivudine and IFNα-1b federatively was more effective than using a single medicine.