血浆1，3-β-D-葡聚糖检测诊断播散性马尔尼菲青霉菌病的价值

Clinical value of the plasma1,3-β-D-glucan detection in the diagnosis of penicilliposis marneffei

目的评价血浆1，3-β-D-葡聚糖检测诊断播散性马尔尼菲青霉菌病的价值。方法以G试验方法定量检测血浆1，3-β-D-葡聚糖浓度。结果在60只播散性马尔尼菲青霉菌病动物模型中，血浆1，3-β-D-葡聚糖浓度随病程延长而逐渐增高，深部真菌感染组与对照组相比有统计学意义（P〈0．01）。敏感性、特异性、阳性预测值和阴性预测值分别为88．3％、100％、100％、58．8％。血浆1，3-β-D-葡聚糖阳性结果明显早于组织病理。结论利用G试验定量检测血浆1，3-β-D-葡聚糖方法简便，结果稳定，可用于播散性马尔尼菲青霉菌病的早期辅助诊断。

Objective To evaluate the clinical value of the quantitative detection of plasma 1,3-β-D-glucan in penicilliposis marneffei. Methods The 1,3-β-D-glucan concentrations were detected by using a G test. Results In 60 New Zealand rabbits infected by PeniciUium marneffei, the levels of 1,3-β-D-glucan were positively correlated with infectious severity. The sensitivity, specificity,positive predictive rate and negative predictive rate were 88.3%, 100%, 100% and 58.8% respectively,which were significantly higher than those of the control group（P 〈0.01 ）. Conclusion The quantitative method for the detection of 1,3-β-D-gIucan in plasma was simple,sensitive and reliable, and could be used as the assisting diagnosis of penicilliposis marneffei at early stage.