154例舒血宁注射液的严重不良反应分析

Analysis of 154 Reports of Serious Drug Adverse Reaction Induced by Shuxuening Injection

目的通过对154例舒血宁注射液严重不良反应发生的情况、特点、症状等方面的详细分析,为临床合理使用舒血宁注射液提供参考。方法收集青海省药品不良反应监测中心数据库中的2004～2009年间舒血宁注射液数据,进行统计与分析。结果严重不良反应的主要损害以皮肤及其附件损害、全身性损害、中枢及外周神经系统损害、胃肠系统损害、呼吸系统损害等为主,占85.62%,共947例次;其中以过敏性休克、呼吸困难、憋气、喉头水肿等为主要严重不良表现,无死亡及后遗症病例。结论应加强舒血宁注射液的合理使用和监测,以避免不良反应发生。

Objective In order to provide reference for clinical rational use of Shuxuening injection by analysis of 154 reports of serious drug adverse reaction induced by Shuxuening injection. Methods 154 reports of serious drug adverse reaction induced by Shuxuening injection were statistical analyzed from 2004 to 2009 in Qinghai Center for ADR monitoring. Results Serious adverse reactions were include skin damage and annex damage, systemic damage, central and peripheral nervous system damage, gastrointestinal system damage/respiratory damage and other accounted for 85.62%. Anaphylactic shock, dyspnean suffocating, laryngeal edema and other is the mainly serious adverse reactions, none of dieth and sequelae case. Conclusion We should enhance the rational use and monitoring of Shuxuening injection to avoid adverse reactions.