化学趋化因子在慢性阻塞性肺疾病中的作用

Role of chemokines in chronic obstructive pulmonary diseases

慢性阻塞性肺疾病（chronic obstructive pulmonary diseases，COPD）是一组以气流受限，且不完全可逆为特征的肺部疾病，认为与肺部对有害气体或有毒颗粒的异常炎症反应有关。目前仍缺乏有效的治疗手段。其诱发慢性炎症的具体细胞分子学机制仍不清楚。然而，越来越多的证据表明香烟诱导的炎症细胞的募集取决于趋化因子及其配体的调节。这里主要探讨CXC-和CC-家族与各种炎性细胞的相互调节，通过阻断趋化因子而减少COPD患者的炎性细胞浸润及实质破坏可能为一种有效的抗炎策略。

Chronic obstructive pulmonary diseases （COPD） is characterized by a limitation of airflow that is not fully reversible and is associated with an abnormal inflammatory response of the airway and lungs to noxious particles and gases. There are also no effective disease-modifying therapies now. The molecular and cellular mechanisms that lead to chronic inflammation of small airways and lung parenehyma are not yet completely unraveled. However, there is now growing evidence that the recruitment of these inflammatory cells in response to cigarette smoke is largely regulated by chemokines which acting as ligands for chemokine receptors. In this review we will focus mainly on the CXC-and CC-family. Blocking chemokine receptors with selective antagonists to inhibit leukocyte recruitment and reduce the parenchymal destruction might be an effective anti-inflammatory strategy in COPD.