C6胶质瘤侵袭机制的研究进展

Research Advancement of Invasion Mechanisms in C6 Glioma

恶性肿瘤的侵袭转移机制是当今肿瘤学研究的热点之一,多形性胶质母细胞瘤(glioblastoma multiforme,GBM)死亡率居高不下的主要原因在于其在脑内发生广泛的浸润,GBM的侵袭是一个受多因素调控、多种基因参与的多步骤、多阶段、连续复杂的主动过程,很多机制还不十分清楚。但是,近年来许多学者通过C6胶质瘤模型对GBM的研究表明,一些黏附分子、蛋白酶及细胞因子等参与C6胶质瘤的侵袭。本文就目前C6胶质瘤侵袭机制的研究进展进行综述。

Invasion and metastasis mechanism of malignant tumor was a hot spot of ontological research for the past few years. Glioblastoma multiforme （GBM） is a kind of malignant tumor with the highest attack rate in China. The reason that it causes the high death rate lies in the wide invasion to brain. The invasion of GBM is a complicated active process related to multiple factors and multiple genes. Many mechanisms are not very clear at the present, but latest studies show that many adhesion molecules, proteases and cytokines involved in invasion of C6 glioma. This article reviewed the research advance of invasion mechanism in C6 glioma.