摘要
树突状细胞(dendritic cell,DC)是目前已知体内最强的抗原提呈细胞(APC),其在肿瘤免疫中具有重要的作用。DC的靶向抗肿瘤治疗成为当今肿瘤免疫治疗的研究热点。本文就DC的抗肿瘤机制、DC基因修饰策略及DC疫苗的临床治疗进展进行综述。
Dendritic cell （DC） which plays an important role in tumor immunity has been known as the most potent antigen-presenting cells in vivo. DC targeted anti-tumor therapy becomes the focus of current tumor immunotherapy. In this paper, the anti-tumor mechanism of DC, DC gene modification strategy and the clinical treatment of DC vaccine are reviewed.
出处
《现代生物医学进展》
CAS
2010年第17期3391-3393,共3页
Progress in Modern Biomedicine
基金
重庆市重大科技专项基金CSTC
2007AB5029
关键词
树突状细胞
基因修饰
DC疫苗
靶向治疗
抗肿瘤免疫
Dendritic cell
Genetically modified
Targeted therapy
DC vaccine
Anti-tumor immunity
