IL-24的生物学特性及其抗肿瘤作用机制

Biological characteristics of IL-24 and mechanisms of its anti-tumor action

目前研究显示，IL-24是惟一既具有抑制肿瘤细胞生长和血管形成又具有免疫刺激作用的细胞因子。其抑制作用不依赖p53、Rb和p16等抑癌基因，对正常细胞没有影响，现已成为肿瘤治疗研究的新热点。

Studies have shown that IL-24 is the only cytokine capable of inhibiting tumor growth and neovascularization as well as stimulating immune system. IL-24 exerts its inhibition effects through pathways independent of p53, Rb, p16 and other tumor suppressor genes and has no effect on normal cells. IL-24 has emerged as a hot topic in cancer therapy research.