摘要
抑癌基因甲基化是当前肿瘤研究的热点领域,它涉及细胞周期调控、细胞间信号转导、DNA凋亡及肿瘤的侵袭转移等过程。抑癌基因甲基化与涎腺腺样囊性癌的发生及其生物学行为密切相关。
Methylation of tumor suppressor gene(TSG), currently a hot field in cancer research, is involved in many biological processes including cell cycle regulation, cell signal transduction, DNA apoptosis, tumor invasion and metastasis. The level of TSG methylation is significantly associated with the development of salivary adenoid cystic carcinoma and its biologic behavior.
出处
《国际肿瘤学杂志》
CAS
2010年第9期676-679,共4页
Journal of International Oncology
基金
浙江省自然科学基金资助项目(Y208660)
关键词
甲基化
抑癌基因
癌
腺样囊性
涎腺
Methylation
Tumor suppressor genes
Carcinoma, adenoid cystic
Salivary glands