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1型糖尿病的免疫干预及其干细胞治疗 被引量：5

lmmunotherapy and stem cell transplantation for the treatment of type 1 diabetes
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摘要 1型糖尿病以自身免疫性胰岛炎为病理特征。免疫干预可作用于胰岛自身免疫过程的不同环节，阻碍胰岛炎的发生与发展。干细胞可诱导分化为胰岛素分泌细胞，且具有免疫调节功能。现对免疫干预及T细胞移植治疗1型糖尿病等方面的最新研究进展进行综述。 Autoimmune insulitis is the main pathological characteristic of type 1 diabetes. Immunotherapies can effectively prevent and/or extenuate autoimmune insulitis by modulating different effectors in the autoimmune response. Stem cells can be induced into insulin-secreting cells, also they can regulate immune function. Here reviews the recent studies on immunotherapies and stem cell transplantation for the treatment of type 1 diabetes.
作者 朱大龙 李莉蓉
机构地区 南京大学医学院附属鼓偻医院内分泌科
出处 《国际内分泌代谢杂志》 2010年第5期289-293,共5页 International Journal of Endocrinology and Metabolism
基金 南京市卫生局重点项目（ZKM05045,ZKX07012）
关键词 1型糖尿病 免疫疗法 干细胞移植 Type 1 diabetes mellitus hnmunotherapy Stem cell transplantation
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献36

  • 1Pietropaolo M,Surhigh JM,Nelson PW,et al.Primer:Immunity and autoimmunity.Diabetes,2008,57:2872-2882.
  • 2Tritt M,Sgouroudis E,Hennezel E,et al.Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes.Diabetes,2008,57:113-123.
  • 3Pozzilli P,Leslie RD.New prospects for immunotherapy at diagnosis of type 1 diabetes.Diabetes Metab Res Rev,2009,25:299-301.
  • 4James AM,Ricordi C,Hering BJ,et al.International trial of the edmonton protocol for islet transplantation.N Engl J Med,2006,355:1318-1330.
  • 5Skyler JS,Krischer JP,Wolfsdorf J,et al.Effects of oral insulin in relatives of patients with type 1 diabetes:The Diabetes Prevention Trial-Type 1.Diabetes Care,2005,28:1068-1076.
  • 6Ludvigsson J.Therapy with GAD in diabetes.Diabetes Metab Res Rev,2009,25:307-315.
  • 7Ludvigsson J,Faresjo M,Hjorth M,et al.GAD treatment and insulin secretion in recent-onset type 1 diabetes.N Engl J Med,2008,359:1909-1920.
  • 8Eldor R,Kassem S,Itamar R.Immune modulation in type 1 diabetes mellitus using DiaPep277:A short review and update of recent clinical trial results.Diabetes Metab Res Rev,2009,25:316-320.
  • 9Edwin L,Marcella L,Jean J,et al.Deleting islet autoimmunity.Cell Biochem Biophys,2007,48:177-182.
  • 10Cernea S,Pozzilli P.New potential treatments for protection of pancreatic β cell function in type 1 diabetes.Diabet Med,2008,25:1259-1267.

二级参考文献7

  • 1Boris N, Yasuo T, Igor L, et al. Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity. Diabetes, 2004,53 : 376-383.
  • 2Voharelli JC, Couri EB, Boris N, et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA,2007,297:1568-1577.
  • 3James AM, Ricordi C, Hering BJ,et al. International trial of the edmonton protocol for islet transplantation. N Engl J Med, 2006, 355:1318-1330.
  • 4Gratwohl A, Passweg J, Bocelli-Tyndall C, et al. Autologous hematopoietic stem cell transplantation for autoimmune diseases. Bone Marrow Transplant, 2005, 35: 869-879.
  • 5Auletta JJ, Lazarus HM. Immune restoration following hemato poietic stem cell transplantation: an evolving target. Bone Marrow Transplant, 2005, 35:835-857.
  • 6Steffes MW,Sibley S, Jackson M, et al. Beta cell function and the development of diabetesrelated complications in the diabetes control and complications trial. Diabetes Care,2003,26:832 836.
  • 7Ianus A, Holz GG, Theise ND, et al. In vivo derivation of glu cose competent pancreatic endocrine ceils from bone marrow without evidence of cell fusion. J Clin Invest, 2003,111:843-850.

共引文献33

同被引文献42

引证文献5

二级引证文献7

国际内分泌代谢杂志
2010年 第5期

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