摘要
催乳素（PRL）在哺乳动物的生长、繁殖及免疫调节中起重要作用。甲状腺疾病与高PRL血症关系密切，PRL可能参与了这些疾病的发生、发展。自身免疫性甲状腺疾病时，PRL可通过刺激辅助性T细胞分泌多种细胞因子而促进甲状腺自身抗体的产生。甲状腺功能减退时，雌激素、促甲状腺激素释放激素（TRH）及垂体血管活性肠肽（VIP）水平可能影响了PRL的分泌。甲状腺癌时PRL可能作为抗细胞凋亡因子或有丝分裂原而发挥作用。
Prolactin （PRL） plays an important role in growth,reproduction and immune regulation in mammal. PRL may be involved in the development of thyroid diseases, since that thyroid diseases are related with hyperprolactinemia. In autoimmune thyroid diseases,hyperprolactinemia can stimulate helper T cells secreting a variety of cytokines to produce lots of thyroid autoantibodies. In hypothyroidism, estrogen,thyrotropin releasing hormone（TRH） and vasoactive intestinal peptide （VIP） may affect the secretion of PRL. In thyroid cancer,prolactin may act as an anti-apoptotic factor or mitogen.
出处
《国际内分泌代谢杂志》
2010年第5期311-313,共3页
International Journal of Endocrinology and Metabolism
