加味小陷胸汤干预湿热困脾型糖耐量受损30例临床研究

Clinical Research of Modified Minor Chest Bind Decoction on IGT of Pattern of Dampness-heat Accumulating Spleen

目的:观察加味小陷胸汤干预湿热困脾型糖耐量受损,评价其疗效。方法:70例湿热困脾型糖耐量受损患者随机分为治疗组(n=33例)和对照组(n=37例),在生活方式干预的基础上,治疗组服加味小陷胸汤,对照组服二甲双胍片,观察治疗前后2组患者证候、血糖、胰岛素释放及其敏感性、胰岛素抵抗指数等改善情况。结果:治疗组患者在证候积分、血糖积分、胰岛素敏感性、体重指数、腰围、臀围与对照组比较有统计学意义。结论:加味小陷胸汤能显著改善患者中医临床症状,降低患者血糖积分,提高胰岛素敏感性,减轻体重,减小腰围,且无不良反应。

Objective：To observe and evaluate the therapeutic effects of modified Minor Chest Bind Decoction on impaired glucose tolerance（IGT） in the pattern of dampness-heat accumulating spleen.Methods：60patients of the abovementioned syndrome were randomized to treatment group （n=30） and control group （n=30）,respectively treated with the decoction and metformin,besides life style intervention. Changes in syndromes,glucose,insulin releasing,insulin sensitivity,insulin resistance exponent were observed.Results：Treatment group was significantly different from control group in syndrome score,glucose score,insulin sensitivity,BMI,waist line,hip line.Conclusion：The decoction can significantly relieve the dampness-heat syndrome,lower glucose,enhance insulin sensitivity,reduce weight and waist line,while having little adverse reactions.