皮肤鳞状细胞癌和基底细胞上皮瘤中c-myc蛋白的表达

Expression of c myc protein in squamous cell carcinoma and basal cell epithelioma

摘要利用鼠抗单克隆抗体ｃｍｙｃ９Ｅ１０３，过氧化物酶的方法，研究用福尔马林固定、石蜡包埋的鳞状细胞癌（ＳＣＣ）３０例和基底细胞上皮瘤（ＢＣＥ）３１例皮损标本中ｃｍｙｃ蛋白的表达情况，其中ＳＣＣ中ｃｍｙｃ蛋白阳性８例，染色是核内着色，强阳性。而ＢＣＥ中仅１例阳性。因此，推测ｃｍｙｃ蛋白过表达可能是恶性肿瘤的一种恶性程度标志。

The expression of c myc protien was studied in formalin fixed, paraffin embedded sections of 30 cases of squamous cell carcinoma(SCC) and 31 cases of basal cell epithelioma(BCE), using monoclonal antibody 9E10 3 and an immunoperoxidase technique Eight(26 7%) SCC showed positive reactions in some of the tumor cells However, there was only one specimen which showed positive reaction in BCE The staining reactions were limited in nuclei and strong in intensitly We guess that c myc may be a mark of malignant degree in malignant tumor