罗红霉素治疗早期梅毒的疗效评价

Pilot study of roxithromycin for treatment of early syphilis

为了观察罗红霉素治疗早期梅毒的疗效，８例青霉素皮试阳性且既往未经驱梅治疗过的早期梅毒患者，口服罗红霉素１５０ｍｇ／次，每日２次，连续１５天，并定期随访，检查皮疹、淋巴结和血清ＲＰＲ滴度。结果示罗红霉素的血清起效时间一般在服完药后的１个月之后，在服完药后的３个月，淋巴结逐渐开始消失，１年后血清反应素转阴率占８７．５％。总之，罗红霉素作为新一代的大环内酯类抗生素，是治疗早期梅毒较理想的替代药物。

Roxithromycin was used to treat 8 penicillin allergic patients with early syphilis, who didnt accept other spirochaeticidal remedies before.Roxithromycin 150mg was given P.O. twice a day for 15 days. Follow up visits for clinical and serological assessment were scheduled at regular intervals.The results showed that the serological response appeared after 1 month, but the enlarged inguinal lymph glands didnt disappear until 3 months. When finishing the observation after one year, cure was documented for 7 of all these patients(87.5%). Briefly, roxithromycin shows promise as an alternative a gent for treatment of early syphilis. Its opitmal dose and duration need to be further studied.