复方红景天防治急性肺损伤的前瞻性研究

Early use of Chinese drug rhadiola compound for patients with post trauma and inflammation in prevention of ALI/ARDS

目的探索创伤感染和胸心手术后急性肺损伤的发病机率和早期防治效果。方法将符合诊断记分标准的创伤、烧伤、胸心手术后１０４例随机分为单号Ａ１、Ｂ１、Ｃ１、Ｄ１早期防治组（ＥＧ）和双号Ａ２、Ｂ２、Ｃ２、Ｄ２常规处理组（对照组，ＣＧ）。防治组除常规处理原发伤病外，加服复方红景天（ＲＣＯ），每日４ｇ，自入院后３～１５天至术后５～７天。对照组不加ＲＣＯ，两组均在相应时间点检查预设指标，分析各组呼吸窘迫综合征（ＡＲＤＳ）发生率与病死率。结果ＣＧ组与ＥＧ组相比各项指标差异显著（Ｐ＜００５，Ｐ＜００１）。ＡＲＤＳ发生率与病死率ＥＧ组比ＣＧ组分别为１３．７％比２８．２％与５０．０％比６９．２％。结论早期应用ＲＣＯ可能降低创伤感染性急性肺损伤发生率。并对发病机理和药物作用进行探讨。

Objective To evaluate the effects of the Chinese drug rhadiola on the preventive treatment of acute lung injury(ALI) caused by post traumatic/inflammatory and thoracic cardiovascular operations. Methods 104 patients who coincede with thier diagnosis and standard scale were divided randomly in to single number groups A 1,B 1,C 1 and D 1(early preventive treatment group EG) and double number groups A 2,B 2,C 2 and D 2(control group CG). The treatment of primary disease both in EG and CG was similarl, but in EG four grams of rhadiola compound(RCO) were used every day for a period of 3 15 days since admission and 5 7 days after operation. The indicators related to ALI in each groups were measured. Results PaO 2,AaDO 2 and hemorrheology were significant in EG than in CG ( P <0 05) or ( P <0 01). The complication rate of ARDS was decreased about of 50 0% in EG than in CG. Conclusions Early use of RCO may protect against major risk factors of ALI/ARDS caused by massive trauma/infection and thoracic cardio operations.