摘要
目的了解子宫内膜异位症(内异症)患者的红细胞免疫功能状况。方法按修正的美国生育协会(RAFS)分类法将38例内异症患者分为3组:Ⅰ、Ⅱ期13例(Ⅰ、Ⅱ期组),Ⅲ期15例(Ⅲ期组),Ⅳ期10例(Ⅳ期组),其中合并有不孕的13例;另设对照组(21例)。应用玫瑰花环试验和聚乙二醇沉淀法,检测各组血液中红细胞补体C3b受体花环(C3bRR)、免疫复合物花环(ICR)、红细胞补体C3b受体花环促进率(RFER)、花环抑制率(RFIR)4项红细胞免疫功能指标和循环免疫复合物(CIC)。结果与对照组比较,内异症各组C3bRR、ICR及RFER均降低(P<0.05或P<0.01),而RFIR与CIC均升高(P<0.05)。另外,这5项指标在内异症各组间均无差异(P>0.05);在内异症未合并不孕与合并不孕者间,亦无差异(P>0.05)。结论内异症患者血清红细胞免疫粘附促进因子减少,红细胞免疫粘附抑制因子增加,由此引起红细胞免疫粘附功能降低,这与内异症的发病可能有关。
Objective To study erythrocyte immune function of patients with endometriosis and
explore the pathogenesis of endometriosis. Methods 38 patients with endometriosis diagnosed
by laparoscopy or laparotomy and 21 normal women as the control were studied. The patients
were divided into three groups by revised American Fertility Society (RAFS) classfication: group
one (stageⅠ,Ⅱ; n =13), group two(stage Ⅲ , n =15), and group three(stage Ⅳ, n =10).
Using rosette formation test and polyethyleneglycol sedimentation methods, the erythrocyte
immune function including C 3b receptor rosette rate (C 3bRR), immune complex rosette
rate(ICR), erythrocyte rosette forming enhancing rate (RFER) and inhibitory rate (RFIR), and
circulatory immune complex (CIC) was determined. Results The C 3bRR, ICR, and RFER of
group one, two, and three were decreased ( P<0.05 or P <0.01), and RFIR and CIC of group
one, two, and three were increased ( P <0.05) when compared with those of the control. All
parameters had no significant difference among group one, two and three. In addition, these
parameters had no significant difference in infertile groups of endometriosis as compared with
those of fertile group. Conclusion The erythrocyte immune function of patients with
endometriosis is depressed, resulting from decreased erythrocyte immune adherence enhancer
and increased inhibitor. These changes of erythrocyte immune function may be related to the
pathogenesis of endometriosis.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1999年第4期207-209,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
子宫内膜异位
红细胞免疫
Endometriosis Erythrocytes Immunity,
cellular Receptors, complement 3B Rosette formation