胶原与假体生物工程材料的对接研究进展

The Development of Collagen′s Perfusion and Ingrowth into the Prosthetic Bioengineering Material

Despite the great progress achieved in orthopaedic biomaterial in the past several decades,the perfusion and ingrowth of the collagen osteoblast into the prosthetic bioengineering materials remains a problem that awaits further investigation.It has been shown that there is a close correlation between the preparation,hence the geometric and biophysico-mechanical properties of the prosthetic biomaterial(implants)and their fixation to the bone host.In this review,an attempt was made to summarize miscellaneous preparation methods in an effort to correlate the preparation arts and the bio-physical-mechanical properties of the implanted materials.The culture method of the collagen osteoblast was also introduced.It had been demonstrated that the pore size,porosity and interconnectivity determine bone and tissue ingrowth into porous implants.3D micro-CT images and structural analyses indicated that the process of perfusion and ingrowth of the collagen osteoblast into the prosthetic bioengineering material had been practically and effectively observed,and the observed histomorphometrical results implied that such a bio-match process could be controlled in a smooth and stepwise way.In a word titanium based prosthetic bio-engineering material holds promise to be an bioengineering material in orthopaedic therapy.

Despite the great progress achieved in orthopaedic biomaterial in the past several decades, the perfusion and ingrowth of the collagen osteoblast into the prosthetic bioengineering materials remains a problem that awaits further investigation. It has been shown that there is a close correlation between the preparation, hence the geometric and biophysieo- mechanical properties of the prosthetic biomaterial（implants）and tlieir fixation to the bone host. In tiffs review, an attempt was made to summarize miscellaneous preparation methods in an effort to correlate the preparation arts and the biophysical- mechanical properties of the implanted materials. The culture method of the collagen osteoblast was also introduced. It had been demonstrated that the loom size, porosity and interconnectivity determine bone and tissue ingrowth into porous implants. 3D micro- CT images and structural analyses indicated that the process of peffusion and ingrowth of the collagen osteoblast into the prosthetic bioengineering material had been practically and effectively observed, and the observed histomor- phometrical results implied that such a bio - match process could be controlled in a smooth and stepwise way. In a word tita- nium based prosthetic hio - engineering material holds promise to be an bioengineering material in orthopaedic therapy.