Graves病血清可溶性白细胞介素-2受体(SIL-2R)的变化及与甲状腺自身抗体的关系

Relationship Between Serum Soluble Interleukin 2 Receptor and Antibody against Thyroid

按临床表现、体征、ＦＴ３、ＦＴ４、ＴＳＨ测定及治疗情况将６３例Ｇｒａｖｅｓ病患者分为未治组与治疗缓解组。用ＥＬＩＳＡ法测定血清ＳＩＬ－２Ｒ。结果显示血清ＳＩＬ－２Ｒ未治组与治疗缓解组相比是显著增高的（Ｐ＜０．０１），但治疗缓解组与正常对照组无差异。血清ＳＩＬ－２Ｒ在未治组与ＦＴ３水平及甲状腺刺激抗体（ＴＳＩ）、甲状腺蛋白抗体（ＴＧ－Ａｂ）滴度呈正相关（ｒ分别为０．６７８、０．５８０、０．７３０，Ｐ均＜０．０１）。

Accoding to the clinical data and the levels of FT 3、FT 4and TSH,63 patients were divided into two groups:Untreated group(A)and treated with carbimazole group(B) Serum SIL 2R was defected by the use of ELISA The results showed that the level of SIL 2R in group A was significantly elevated(P<0 01)when compared with group B; but there was no difference befween group B and the control;In group A,serum SIL 2R was correlated with levels of FT 3,TSI and TG Ab (r=0 678,0 580,0 730, P<0 01) The results suggested that the level of SIL 2R was a valuable immunologic indicator to assess the activity and therapeutic effects of GD