氟康唑治疗肾移植术后真菌感染

Fluconazole in treating the fungal infection after renal transplantation

目的：探索氟康唑治疗肾移植术后真菌感染的剂量、疗程及疗效。方法：肾移植术后真菌感染患者３３例，男２７例，女６例，年龄（３９±１０）ａ。用氟康唑２００ｍｇ，静滴ｂｉｄ，疗程７～１０ｄ，临床症状减轻后改用氟康唑１００ｍｇ，ｐｏ，ｂｉｄ，维持治疗，时间为１５～２０ｄ。结果：临床有效率９０９０％，显效时间、疗程均比较满意，氟康唑的不良反应较轻。结论：氟康唑为治疗肾移植术后真菌感染的有效药物。

OBJECTIVE: To explore the effect of fluconazole in treating the fungal infection after reanl transplantation. METHODS: 33 patients with fungal infection after renal transplantation (M 27,F6;ages 39s10a) were given fluconazole 200mg,vein drop,bid,from 7 to 10 days.When their clinical signs were alleviate,the dosage of fluconazole was decreased to 100mg,po,bid from 15 to 20 days for supporting treatment. RESULTS: The clinical efficacy rate was 99.90%,the time and period of treatment was also satisfied.The adverse reaction of fluconazole was very little. CONCLUSION:WTFluconazole were effective drugs for treating the fungal infection after renal translpantation.