幽门螺杆菌感染与冠心病的相关性研究

Relation between helicobacter pylori infection and coronary heartdisease

目的 :探讨幽门螺杆菌 ( HP)感染与冠心病 ( CHD)的关系。方法 :用酶联免疫法检测了74例 CHD患者和 5 4例其他心血管疾病患者的血清 HP特异性 Ig G抗体 ( HPIg G) ,以及血清总胆固醇、甘油三酯 ( TG)、一氧化氮 ( NO)浓度。结果 :47例 ( 63.5 % ) CHD患者 HPIg G阳性与对照组 2 4例 ( 42 .9% ) HPIg G阳性比较有显著性差异 ( OR:2 .3,χ2 :5 .4873,P <0 .0 5 ) ,HPIg G阳性病例的血清 TG浓度明显高于 HPIg G阴性病例 ( P <0 .0 1)。HPIg G阳性病例血清 NO浓度较 HPIg G阴性病例有降低趋势 ,但无显著性。结论 :HP感染与 CHD可能有明显的关系 ,其可能的机理是 HP感染改变了血脂浓度来增加发生 CHD的危险性。

Objective:To determine the relation between helicobacter pylori( HP) infection and coronary heart disease ( CHD) .Methods:Serum specific Ig G antibodies to HP( enzyme linked im- munosorbent assay) and serum concentrations of total cholestesterol( TC) ,triglyceride( TG) and nitric oxide ( NO) were measured in 74patients with CHD and 5 6controls with other cardiovascu- lar diseases.Results:47of the CHD cases( 63.5 % ) were seropositive for HP compared with2 4of the controls ( 42 .9% ) were positive ( OR 2 .3,χ2 5 .4873,P <0 .0 5 )。 Those who were HP positive had significantly( P <0 .0 1) higher concentrations of TG than those who were HP negative.The concentrations of NO tended to be lower in those who were HP positive than in those who were HP negative,but the trend was non- significant.Conclusions:HP infection was associated with CHD. Possible mechanism was that HP infection might modify the serum lipid concentrations in a way that could increase the risk of CHD.