心肌生长因子对兔实验性心肌梗死范围的影响

Influence of myocardium growth factor(MGF) on experimental myocardial infarctsize from rabbits

目的 :研究心肌生长因子 ( MGF)对兔心肌梗死范围的影响。方法 :用心电图 ST段抬高总值、ST段抬高≥ 2 mm导联数和病理性 Q波导联数标测法结合硝基四氮唑蓝大体标本染色观测MGF对高位双重结扎兔冠状动脉前降支后造成的急性心肌梗死范围的影响。结果 :在结扎冠状动脉前降支 7d内 ,MGF大剂量组及小剂量组均能使结扎前降支所引起的 ST段抬高减轻 ,ST段异常抬高导联数减少 ,病理性 Q波数减少 ,ST段恢复至等电位线的时间提前 ,升高的肌酸激酶值降低 ,梗死心肌重量占左室重量的百分率减小 ,与生理盐水对照组比较有显著性差异 ( P <0 .0 5 )。结论 :MGF能缩小兔实验性心肌梗死范围。

Objective:To research the influence of myocardium growth factor ( MGF) on ex- perimental myocardial infarct size from rabbits.Method:Influences of MGF on experimental acute myocardial infarct size brought by high positioned double- ligation of the anterior descending left coronary artery of40 rabbits were observated byΣ ST,NST,NQ mapping in electrocardiogram,CK in combination with N- BT macroscopic staining.Result:Within 7days after ligation of the coronary artery,each of large dose group and small dose group of MGF could cause that elevation of ST seg- ment was decreased,leads of elevated ST segment and pathologic Q- wave were descreased,the time that ST segment recovered to isopotential line reduced,elevated CK were descreased,the percent- age of infarct myocardial weightof left ventricle desceased.Conclusion:Experimental myocardial in- farct size in rabbit might be reduced by MGF.