治疗2型糖尿病3种用药方案的成本-效果分析

Cost-effectiveness analysis of 3 different drugs in the treatment of type 2 diabetes mellitus

目的:比较3种用药方案治疗2型糖尿病药物的成本-效果。方法:将204例2型糖尿病患者随机分成三组,分别用A(阿卡波糖组),B(格列齐特组)和C(吡格列酮组)治疗。结果:A、B、C组药物治疗成本分别是632.52元、245.28元、442.68元,对空腹血糖的总有效率为79.41%、77.27%、68.57%,成本效果比分别是796.52、317.43、645.59。对餐后2h血糖的总有效率为86.76%、84.85%、81.43%,成本效果比分别是741.61、289.07、534.25。A、C组相对于B组的增量成本-效果比分别(空腹血糖/餐后2h血糖)为180.95/202.74、22.69/57.72。结论:三组用药方案都能将血糖控制在相对理想范围,就经济成本分析,以B组用药方案是3种方案中最具临床推广价值的治疗方案。

Objective：To discuss the cost-effectiveness of 3 different drugs in the treatment of type 2 diabetes mellitus.Methods：204 cases with type 2 diabetes mellitus were randomized to 3 groups.Group A was treated with Acarbose;group B was treated with Gliclazide and group C was treated with Pioglitazone.Results：The treatment costs for A,B and C 3 schemes were 632.52,245.28 and 442.68 yuan respectively;the total effective rates on blood-fasting sugar were 79.41%,77.27% and 68.57% respectively,the cost-effectiveness of the three rates on blood-fasting sugar were 796.52,317.43 and 645.59 respectively.The total effective rates on blood sugar 2 hours after meal on blood-fasting sugar were 86.76%,84.85% and 81.43% respectively,the cost-effectiveness of the three rates on blood sugar 2 hours after meal on blood-fasting sugar were 729.05,289.07 and 543.63 respectively.The cost-effectiveness ratio increments of scheme（FPG/2 hPG） A and C were 180.95/202.74,22.69/57.72.Conclusion：Blood sugar level can be controlled to an ideal level through the three treatment schemes,analysis of the economic costs,B group therapy programs are the most valuable clinical treatment programs of three treatment schemes.