鼻赘型酒糟鼻组织病理学分析

Histopathological analysis and study of rhinophyma(late-stage rosacea)

目的观察鼻赘型酒糟鼻组织病理学改变,讨论鼻赘型酒糟鼻组织病理学改变与蠕形螨寄生的关系。方法收集17例酒糟鼻患者标本,AAF液固定,石蜡包埋切片,HE染色后作组织病理学观察和分析。结果 1)病变部位表皮增生伴角化过度,角质栓形成,真皮纤维结缔组织增生,毛细血管增生、充血,毛囊口扩张,毛囊和血管周围有炎细胞浸润,皮脂腺呈袋状增生;2)鼻赘型酒糟鼻患者蠕形螨感染率为100%,且多为中、重度感染,病理学改变严重程度与感染螨虫数量呈正相关。结论鼻赘型酒糟鼻组织病理学改变与人体蠕形螨寄生有密切关系,中、重度蠕形螨感染是鼻赘型酒糟鼻发病和加重的重要因素。

Objective To observe histopathological changes of rhinophyma（late-stage rosacea）and to discuss the relationship between the Demodex parasite and histopathological changes of rhinophyma（late-stage rosacea）.Methods Seventeen skin specimens of patients with rosacea were collected.After AAF liquid fixation,paraffin embedding,and sectioning,HE staining was performed along with histopathological observation and analysis.Results（1）Epidermal hyperplasia was associated with hyperkeratosis,keratin plug formation,varying degrees of fibrous connective tissue proliferation,and superficial dermal capillary proliferation,congestion,and expansion.Skin samples had irregular expansion of follicles,infiltration of inflammatory cells,and expansion of sebaceous glands in the form of pockets.（2）Most Demodex mite infections were moderate to severe,and there was a positive correlation between the number of infecting mites and the severity of pathological changes.Conclusion There is quite a close relationship between the human Demodex parasite and the histopathological changes of rhinophyma（late-stage rosacea）.Infection by a large number of mites plays a decisive role in the pathogenesis of rosacea.