原发性双侧肾上腺非霍奇金淋巴瘤(附2例报告并文献复习)

Primary Bilateral Adrenal Non-Hodgkin' s Lymphoma (2 Cases Report and A Review of Literatures)

目的:探讨肾上腺原发性非霍奇金淋巴瘤的临床特征及治疗。方法:结合文献回顾性分析2例双侧肾上腺原发性非霍奇金淋巴瘤的临床病理资料。结果:1例患者误诊,行左侧肾上腺肿瘤切除,生存2.1年。1例患者CT介导下穿刺活检明确诊断后,未手术治疗,生存2.7年。诊治过程中2例均发生中枢神经系统的延迟复发,复发后经放化疗,分别生存8个月和14个月。结论:原发性肾上腺恶性淋巴瘤是一种罕见的恶性度较高的肿瘤,预后差。治疗应以化疗为主。易发生中枢神经系统的延迟复发,治疗过程中应行脑部CT检查密切监测。

Objective： To study the clinical features and treatment of Primary Bilateral Adrenal Non-Hodgkin＇ s Lymphoma. Methods ： Clinical pathological features of 2 cases of Primary Bilateral Adrenal Non-Hodgkin＇ s Lymphoma were analyzed retrospectively and literatures were reviewed. Results： One case was misdiagnosed who accepted the left adrenal tumor resection, living for 2. 1 years. Another was given the CT-mediated puncture biopsy to identify the final diagnosis, and alive for 2.7 years without operation. The delayed recurrence in CNS occurred in both cases, and the patient were alive for 8 and 14 months respectively after radiotherapy and chemotherapy. Conclusion ： Primary Bilateral Adrenal Non-Hodgkln＇ s Lymphoma rarely occures with poor prognosis and high degree of malignancy. Chemotherapy should be the best way for the treatment. Delayed recurrence of the CNS prones to occur, so the brain CT examination should be performed in the course of treatment for close monitoring.