Tp—e时间及离散度对Brugada综合征患者预后的分析

The Analysis for Prognosis of Patients with Brugada Syndrome Using Tp-e Interval and Dispersion

目的探讨T波峰-末时间（Tp—e时间）及离散度与Brugada综合征患者预后的关系。方法采用动态心电图分析仪测量31例Brugada综合征患者的Tp—e时间及离散度。随访2～6年，每年2次，心脏事件为猝死幸存和（或）发生室性心动过速／心室颤动。结果无症状者发生心脏事件的Tp—e时间及离散度分别为（116．00±8．94）ms、（3300±1150）ms；未发生心脏事件者分别为（8666±1000）ms、（22．00±6．30）ms，差异有显著统计学意义（均P〈0．01）。有症状者再发生心脏事件的Tp—e时间及离散度分别为（108．50±10．69）ms、（3420±1060）ms；未发生心脏事件者分别为（85．45±9．34）ms、（18．10±12．60）ms，差异有显著统计学意义（均P〈0．01）。Tp—e时间及其离散度预测心脏事件发生的ROC曲线下面积分别为0947、0703。结论Tp—e时间及离散度可作为一种无创手段用于预测Brugada综合征患者发生心脏事件。

Objective To evaluate the association between Tpeak-Tend interval （Tp-e） or Tp-e dispersion and prognosis in patients with Brugada syndrome. Methods Tp-e and Tp-e dispersion were measured automatically by ambulatory ECG apparatus in 31patients with Brugada syndrome. Cardiac events such as, aborted sudden death, ventricular tachycardia and fibrillation were evaluated during followed-up 2 to 6 years. Results In patients without previous symptoms, those with cardiac events had significantly prolonged Tp-e and Tp-e dispersion [（116.00 ± 8.94） ms, （33.00 ±11.50） ms], compared with those without cardiac events[（86.66 ± 10.00） ms, （ 22.00 ± 6.30） ms] （P 〈0.01）. In patients with previous symptoms, those with cardiac events had significantly prolonged Tp-e and Tp-e dispersion[（108.57 ± 10.69） ms, （34.20 ± 10.60） ms], compared with those without cardiac events [（85.45± 9.34） ms, （18.10 ± 12.60） ms] （P〈0.01）. The area under the receiver operating characteristics curves of Tp-e and Tp-e dispersion for occurrence of cardiac events was 0.947,0.703. Conclusion Tp-e may be used to predict cardiac events in patients with Brugada syndrome.