超声造影技术定量评价正常人肝脏血流灌注及方法学研究

Quantitative evaluation of real time contrast-enhanced ultrasonography in examination of normal liver perfusion.

目的评价肝实质超声造影参数定量分析正常人肝脏血流灌注的可行性。方法对29例健康人进行肝脏超声造影检查,应用QLAB分析软件,将肝实质作为感兴趣区(ROI)绘制时间-强度曲线(TIC),测算肝动脉灌注时间(Ta),肝实质灌注达峰时间(Tpeak),门静脉灌注时间(Tp),肝动脉灌注强度(Ia),肝实质灌注强度(Ipeak),门静脉灌注强度(Ip),肝动脉-肝实质灌注强度比(Ia/Ipeak)和肝动脉-门静脉灌注强度比(Ia/Ip)。并用TIC曲线对肝实质设置的不同大小的ROI进行定量灌注参数对比分析。结果实时超声造影能清晰显示肝脏灌注的过程。肝实质不同面积ROI测得的Ta、Tpeak、Ia、Ipeak、Ia/Ipeak、Ia/Ip等之间差异无统计学意义(P>0.05)。结论实时谐波超声造影技术能定量分析肝实质血流灌注的特点,不同的ROI在同一灌注参数的测量上具有一致性。

Objective To evaluate the feasibility of real time contrast-enhanced ultrasonography（CEUS） in quantitative analysis of perfusion in normal liver.Methods Twenty-nine healthy volunteers were included in this study,real time contrast-enhanced imaging of blood perfusion in liver was successively examined,and time-intensity curves（TIC） were drawn at interested regions of liver parenchyma by using QLAB analyzing soft ware.Some quantitative parameters were obtained,including peak intensity of arterial perfusion（Ia）,peak intensity of total perfusion（Ipeak）,intensity of portal venous perfusion（Ip）,the ratio of arterial perfusion and total perfusion（Ia/Ipeak）,the ratio of arterial perfusion and portal venous perfusion（Ia/Ip）,arrival time to the peak of arterial perfusion（Ta）,arrival time to the peak of total perfusion（Tpeak）,and lasting time of portal venous perfusion（Tp）.All quantitative data were compared among different regions of interest（ROIs）.Results CEUS showed clear imaging of perfusion in liver parenchyma.In comparison with different ROIs,there was no statistical difference among all these quantitative parameters of Ta、Tpeak、Ia、Ipeak、Ia/Ipeak and Ia/Ip respectively（P 0.05）.Conclusion CEUS can precisely display the quantitative perfusion of liver parenchyma.Perfusion data of different ROIs have good compatibility.