中药复方——冠心舒钙拮抗作用的研究

STUDIES ON THE ANTAGONISTIC EFFECT OF COMPLEX PRESCRIPTION GUAN XIN SHU DECOCTION

利用４５Ｃａ跨膜测量技术对中药复方——冠心舒治疗冠心病的研究结果表明，冠心舒不影响大鼠主动脉静流钙通道（ｌｅａｋ）的Ｃａ２＋内流，而对ＲＯＣ和ＰＤＣ的Ｃａ２＋内流有拮抗作用．当浓度为３０×１０－３ｇ／ｍＬ时，该药促使ＰＤＣ和ＲＯＣ的Ｃａ２＋内流量分别比对照下降２９×１０－６ｍｏｌ／ｋｇ和３６×１０－６ｍｏｌ／ｋｇ．这就说明，冠心舒治疗冠心病的药理，与阻滞钙通道和减少Ｃａ２＋内流有关．经拆方分析表明。

The complex prescription Guan Xin Shu (G.X.S),composed of herba epiddii,carthamus tinctorius L salvia miltiorrhiza and angelical sinengis were studied.The results show that G.X.S decoction has the antagonistic effect on Ca 2+ influx of ROC and PDC in rat aorta by using 45 Ca transmembrane influx technique,and the antagonistic effect leads the Ca 2+ influx of ROC and PDC to decreasing 29×10 -6 mol/kg and 36×10 -6 mol/kg respectively by comparison with the control group as the extract is 30×10 -3 g/mL.Passing through the analysis of functional groups it indicates that the antagonistec effect of the complex prescription may be related to the results of cooperative effect with the essence of the kidney and the activation of the blood.