抗菌药物治疗溃疡性结肠炎临床疗效再评价—Meta分析

A Meta-analysis on re-evaluaation of antibiotics in treatment of active ulcerative colitis

目的系统评价抗菌药物辅助治疗溃疡性结肠炎的疗效。方法文献检索并收集抗菌药物辅助治疗活动期慢性溃疡性结肠炎的随机、双盲、对照临床试验,并行Meta分析。结果抗菌药物对于活动期溃疡性结肠炎临床诱导缓解,其疗效优于安慰剂,但溃结并发症的发病率,组间比较无统计学差异。口服抗菌药物组治疗活动期溃结,其临床诱导缓解率高于安慰剂组,但静脉使用抗菌药物与安慰剂相比较,两者临床诱导缓解率无显著性差异。结论抗菌药物辅助治疗活动期溃结,有助于提高临床诱导缓解率,但不能预防其并发症的产生。口服抗菌药物对活动期溃结可以增高临床诱导缓解率,而静脉给药效果差。

Objective： To systematically evaluate the efficacy of antibacterial therapy in ulcerative colitis.Methods A meta-analysis of randomized,placebo-controlled trials of antibacterial drugs as adjunctive treatment of chronic,active ulcerative colitis was processed.Results Significant difference in reduction of clinical remission was shown between antibiotics treatment group and the placebo group.No significant difference in the incidence of complications of UC was found between the treatment group and the control group.Sensitivity analysis was in favor of oral therapy in comparison with placebo,while no significant difference in reduction of clinical remission was shown between intravenous administration group and the placebo group.Conclusion Increased clinical remission induced by antibiotics in conjunction with conventional drugs proved effective in active UC,but not in favor of the indication for complications of UC.Compared with placebo,active UC responded to oral intake of antibiotics rather than to intravenous administration.