三唑硫酮氨席夫碱吗啡亚甲胺的超声辐射合成及其生物活性

Ultrasonic Radiative Synthesis and Biological Activities of Morpholinomethylamino Containing 1,2,4-Triazole-5-thiones

在超声辐射和常规加热条件下合成了11种未见报道的1-(吗啡啉亚甲基)-3-(3,4,5-三甲氧基苯基)-4-(取代次甲亚胺基)-1,2,4-三唑-5-硫酮。其结构经1HNMR、13CNMR、IR以及元素分析确证。初步生物活性测试结果表明,在500mg/L浓度下化合物对黄瓜花叶病毒(CMV)有一定抑制活性。

Eleven 1-（morpholinomethyl）-3-（3,4,5-trimethoxyphenyl）-4-substitute deneamino-1,2,4triazole-5-thiones were designed and synthesized by means of an ultrasonic radiation method and a traditional heating process.Their structures were characterized by 1H NMR,13C NMR,IR and elemental analyses.Preliminary bioassay shows that some of them exhibit certain inactivities to Cucumber mosaic virus（CMV）.