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白细胞介素-17在妇科肿瘤中的研究进展 被引量：5

Updated Progress of Interleukin-17 in Gynecological Tumors
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摘要 白细胞介素(interleukin,IL)-17是一类主要由活化CD_4^+T淋巴细胞产生的具有促炎作用的细胞因子,有较强的招募中性粒细胞、促进多种细胞释放炎性因子、促进细胞增殖等多种生物学作用,同时参与机体免疫应答、炎症反应及自身免疫性疾病。目前研究发现,IL-17在肿瘤发生发展过程中发挥重要作用。本文就白细胞介素-17与卵巢癌、宫颈癌及绒毛膜癌等妇科恶性肿瘤的关系,综述如下。 Interleukin（IL）-17 is a pro-inflammatory cytokines mainly produced by activated CD_4~＋ T lymphocytes,which involved in the immune response,inflammation and autoimmune diseases,with biological functions of strong recruitment of neutrophils,promoting a variety of cytokines release inflammatory factors and cell proliferation.Present study found that interleukin-17 is significant in tumor development.This article focus on the relationships among interleukin-17 and ovarian cancer,cervical cancer,choriocarcinoma and other gynecological tumors.
作者 青文婕 吕莎 侯倩男 郄明蓉
机构地区 四川大学华西第二医院妇产科
出处 《中华妇幼临床医学杂志（电子版）》 CAS 2010年第5期363-366,共4页 Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
关键词 白细胞介素-17 辅助性T细胞 癌症 interleukin（IL）-17 T helper cell cancer
分类号 R737.3 [医药卫生—肿瘤]
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参考文献8

  • 1Park H,Li ZX,Zhang XO,et al.A distinct lineage of CD4+ T cells regulates tissue inflammation by producing interleukin 17[J].Nat Immunol,2005,6(11):1133-1141.
  • 2Charles KA,Kulbe H,Soper R,et al.The tumor -promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans[J].J Investigat,2009,119(10):3011-3023.
  • 3Miyahara Y,Odunsi K,Chen W,et al.Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer[J].T Proc Natl Acad Sci USA,2008,105(40):15505-15510.
  • 4Pongcharoen S,Niumsup P,Sanguansermsri D,et al.The effect of interleukin-17 on the proliferation and invasion of JEG-3 human choriocarcinoma cells[J].Am J Reprod Immunol,2006,55(4):291-300.
  • 5Muneo N,Mika W,Takashi S,et al.IL-17 enhances the net angiogenic activity and in vivo growth of human hon-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis[J].J Immunol,2005,175(9):6177-6189.
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同被引文献37

  • 1朱雄增.学习和掌握肿瘤的WHO分类,提高病理诊断和研究的水平[J].中华病理学杂志,2006,35(11):646-650. 被引量：14
  • 2Park H,Li ZX,Zhang XO,et al.A distinct lineage of CD4+T cells regulates tissue inflammation by producing interleukin 17[J].Nat Immunol,2005,6(11):1133-1141.
  • 3Numasaki M,Fukushi J,Ono M,et al.Interleukin 17 gene transfection into murine fibrosarcoma cell line MCA increases tumorigenicity correlated with enhanced tumor microuascularity[J].Blood,2003,101(7):2620.
  • 4Takahashi H,Numasaki M,Lotze MT.Interleukin -17 enhances bFGF-,HGF-and VEGF-induced growth of vascular endothelial cells[J].Immunol Lett,2005,98(2):189.
  • 5Hwang SY,Kim JY,Kim KW,et al.IL-17induces production of IL-6 and IL-8 in rheumatoid arthritis synovialfibroblasts via NF-kappaB-and PI3-kinase/Akt-dependent pathways[J].Arthritis Res Ther,2004,6:R120.
  • 6Fossiez F,Djossou O,Chomarat P,et al.T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines[J].J Exp Med,1996,183:2593.
  • 7Park H,Li ZX,Zhang XO,et al.A distinct lineage of CD4+T cells regulatestissue inflammation by producing interleukin 17[J].Nat Immunol,2005,6(11):1133.
  • 8Zhang Jp, Yan J, Xu J, et al. Increased intratumoral IL-17-producing ceils correlate with poor survival in hepatocellular carcinoma patients [J].J Hepatol, 2009, 50 (5): 980-989.
  • 9谢幸,苟文丽.妇产科学[M].北京:人民卫生出版社,2013:359.
  • 10DIMAIO D, LIAO J B. Human papillomaviruses and cervical cancer [J]. AdvVirusRes, 2006, 66: 125-159.

引证文献5

二级引证文献38

中华妇幼临床医学杂志（电子版）
2010年 第5期

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