疏肝益肾法对乳腺癌术后内分泌治疗者雌二醇、孕酮及脂肪酸合成酶的影响

The effect of TCM method of regulating liver Qi and tonifying kidney Yin on plasma concentration of E2, P and FAS of post-surgery breast-cancer patients received endocrine therapy （Tamoxifen）

目的 观察疏肝益肾法对乳腺癌术后内分泌治疗患者血中雌二醇（E2）、孕酮（P）及脂肪酸合成酶（FAS）水平变化的影响.方法 采用随机、平行、同期手段,通过美国Abbott实验室注册的AXSYM系列实验方法检测疗前疗后血浆E2、P及FAS水平.结果 生化检测结果发现观察组与对照组及观察组治疗前后的血浆E2、P及FAS水平变化没有统计学意义,提示TAM的副作用与血浆E2、P及FAS水平无关.结论 由此推测还存其他与血浆激素水平浓度不直接相关的诱发乳腺癌途径.

Objective The prospective study was trying to explore the altering tendency of plasma concentration of E2, P and PAS after TCM intervention for post-surgery breast cancer patient who received endocrine therapy （tamoxifen）.Methods By randomization, parallel, coincidence measures and the lab. technologies of AXSYM registered at Abbott lab. in the USA, plasma concentration of E2, P and FAS were tested before and after treatment. Results The results of biochemical test of plasma E2, P and FAS concentration of the two arms showed no significance difference before and after the intervention,indicating the side effects relating to TAM had nothing to do with plasma E2, P and FAS level. Conclusion It could be predicable that there must be some other by-pass ways initiating breast cancer rather than the way directly altering the level of plasma concentration of E2, P and FAS.