壮骨颗粒对退变性膝骨性关节炎关节液中IL-1β、TNF-α水平的干预作用

Intervention of Zhuanggu granule on IL-1β and TNF-α level of the patients with osteoarthritis

目的 探讨壮骨颗粒对退变性膝骨性关节炎患者关节液中自细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）水平的影响.方法 选择期退变性膝骨性关节炎完成实验的60例患者,在知情同意下,按Doll氏分组法分为壮骨颗粒组30例、硫酸氨基葡萄糖组15例、透明质酸钠组15例,各组分别给药4周,比较治疗前后关节液中IL-1β、TNF-α水平的变化.结果 治疗后,壮骨颗粒组膝关节液中IL-1β、TNF-α水平明显降低,与硫酸氨基葡萄糖组、透明质酸钠组比较差异有统计学意义.结论 壮骨颗粒对退变性膝骨性关节炎膝关节中IL-1β、TNF-d水平有影响.

Objective To investigate the influence of Zhuanggu granule on the concentration of IL-1β and TN-F-α in knee cavity of patients with knee degenerated osteoarthritis. Methods A total of eighty patients with knee degenerated osteoarthritis were recruited into a Zhuanggu granule group （30 cases）, a Sulphuric acid Glucosamine group （15 cases） and a Sodium Hyaluronate group （15 cases） according to Doll grouping method. After all groups were treated for 4 weeks, the changes of concentration of IL-1β and TNF-α was detected before and after the therapy Results After the treatment, the concentration of IL-1β and TNF-α in Zhuangu granule group was significantly lower than the other two groups （Sodium Hyaluronate and sulphuric Glucosamine group）. Conclusion Zhuangu Granule could influence the concentration of IL-1β and TNF-α in patients of knee degenerated osteoarthritis.