中药制剂产后康复宁的药理研究

Pharmacological Study on Traditional Chinese Medicine Chanhoukangfuning

应用ＬＭＳ－２Ｂ二道生理记录仪及配套装置，通过免疫器官重量法和鸡红细胞（ＣＲＢＣ）作免疫原的溶血素（ＩｇＭ）测定法及体内抑菌试验法，观测了中药制剂产后康复宁对家兔离体、在位子宫和小鼠免疫功能的影响，以及对感染大肠杆菌Ｋ８８小鼠的保护作用。结果表明，产后康复宁可使兔离体子宫收缩频率显著增加（Ｐ＜０．０１），张力显著增强（Ｐ＜０．０１），振幅显著增高（Ｐ＜０．０１）；与麦角相比，仅５ｍｉｎ相同时间的子宫收缩频率差异明显（Ｐ＜０．０５），其余相同时间子宫收缩频率、张力、振幅均无明显差异（Ｐ＞０．０５）。使在位子宫收缩频率明显增加（Ｐ＜０．０５），张力明显增强（Ｐ＜０．０５），振幅明显增高（Ｐ＜０．０５）；与麦角比较，子宫收缩频率、张力、振幅在５、１０ｍｉｎ相同时间内差异均不明显（Ｐ＞０．０５）。对免疫功能的影响，不但使小鼠脾脏显著增重（Ｐ＜０．０１），而且溶血素明显增多（Ｐ＜０．０５）。对感染大肠杆菌Ｋ８８的小鼠有明显的保护作用（Ｐ＜０．０５）。提示产后康复宁有增强子宫收缩，促使宫内恶露排除，加速子宫复旧，增强机体免疫功能等作用。

Effects of Chanhoukangfuning on uterus in vitro and in vivo in rabbits and on immunologic function and protection from infection of E.coli K88 in mice were observed by LMS2B recorder and so on. The results showed that Chanhoukangfuning increased contractive frequence, tension and range of uterus in vitro in rabbits during first five minutes (P<0.01) and increased spleen weight and hemolysin significantly in mice (P<0.01), and that Chanhoukangfuning inhibited E.coli K88 in vivo from the mice infected by the bacteria (P<0.05). The study suggested that Chanhoukangfuning not only enhanced uterus contraction so as to eleminate pus and accelerate uteruss recovery, but also improved immunologic function and inhibited bacteria.